Table 4.
Changes in TNF-α, IL-6, IL-8, SOD, and MDA levels at different time points (n=58, x̅ ± sd)
| Indicator | Group | T0 | T1 | T2 | T3 | F | P |
|---|---|---|---|---|---|---|---|
| TNF-α (pg/mL) | Observation group | 34.20±7.48 | 44.20±8.46 | 55.14±12.60 | 37.50±9.10 | 4.164 | 0.047 |
| Control group | 35.00±7.52 | 46.30±8.70 | 72.10±14.86 | 49.00±7.54 | 4.838 | 0.040 | |
| t | 0.391 | 0.635 | 5.896 | 4.318 | |||
| P | 0.530 | 0.436 | 0.034 | 0.044 | |||
| IL-6 (pg/mL) | Observation group | 13.28±4.10 | 19.50±6.44 | 28.46±9.30 | 17.20±6.18 | 5.682 | 0.036 |
| Control group | 13.35±4.06 | 20.10±6.58 | 39.20±7.48 | 25.11±5.70 | 6.175 | 0.024 | |
| t | 0.281 | 1.112 | 5.835 | 5.984 | |||
| P | 0.712 | 0.134 | 0.033 | 0.030 | |||
| IL-8 (pg/mL) | Observation group | 9.41±1.42 | 12.80±2.91 | 16.71±2.81 | 13.60±4.31 | 4.211 | 0.042 |
| Control group | 8.92±1.23 | 13.32±1.71 | 20.93±3.40 | 16.54±3.42 | 6.456 | 0.033 | |
| t | 1.001 | 0.728 | 4.825 | 4.118 | |||
| P | 0.148 | 0.479 | 0.041 | 0.048 | |||
| SOD (U/mL) | Observation group | 439.12±27.24 | 402.43±18.23 | 346.08±17.41 | 389.35±15.32 | 5.425 | 0.037 |
| Control group | 441.23±25.06 | 389.45±16.61 | 326.25±14.35 | 361.71±16.28 | 6.634 | 0.021 | |
| t | 0.414 | 4.112 | 6.927 | 9.732 | |||
| P | 0.668 | 0.000 | 0.000 | 0.000 | |||
| MDA (mmol/L) | Observation group | 4.85±0.16 | 5.77±0.34 | 6.59±0.32 | 5.21±0.17 | 4.009 | 0.046 |
| Control group | 4.89±0.20 | 6.15±0.25 | 7.25±0.26 | 6.18±0.32 | 6.082 | 0.035 | |
| t | 1.189 | 6.857 | 12.191 | 20.387 | |||
| P | 0.237 | 0.000 | 0.000 | 0.000 |
Note: T0: before anesthesia induction, T1: immediately after endotracheal intubation, T2: 1 h after one-lung ventilation; T3: 10 min before the end of operation. TNF-α: tumor necrosis factor-α; IL-6: interleukin-6; IL-8: interleukin-8; SOD: superoxide dismutase; MDA: malondialdehyde.