Fig. 4.

Molecular docking of viral spike RBD domain onto the structure of α5β1 (PDB ID: 3VI3) and αvβ6 (PDB ID: 5FFG) showing interaction via the RGD motif present in the spike RBD domain (A). The molecular docking of viral spike RBD domain onto the structure of α5β1 (PDB ID: 3VI3) showed that the spike RBD is interacting with the α5β1 through its RGD motif in the same way (B, left panel) as synthetic RGD peptide binds and interact to α5β1 (PDB ID: 3VI4) (B, right panel) as already known in literature (Nagae et al., 2012). The docking was done using HDOCK server (hdock.phys.hust.edu.cn/). Spike protein is shown in red and synthetic RGD peptide is shown in green. (For interpretation of the references to colour in this figure legend, the reader is referred to the web version of this article.)