Table 2.
Artificial neural network based predicted motifs in the protein sequence of SARS-CoV-1 and SARS-CoV-2.
| S.No. | Motifs | Position |
||
|---|---|---|---|---|
| HCoV-1 | HCoV-2 | Motif’s Role/Function | ||
| 1 | S1 Glycoprotein | 268–304 | 519–592 | Viral attachment |
| 2 | Potato Inhibitor 1 | 309–320 | Not predicted | NA |
| 3 | Spike Receptor Binding domain | 317–569 | 330–583 | Attachment with host cells |
| 4 | RGD | Not Predicted | 403–405 | Possibly attachment with host cells |
| 5 | FMRP | 437–447 | Not predicted | NA |
| 6 | S2 Glycoprotein | 641–1247; 694–1237 | 684–1265; 712–1255 | Fusion of viral and cell membrane as well as fusion of infected cells with adjoining cells. |
| 7 | Borrelia Repeat | 662–679 | Not Predicted | NA |
| 8 | DUF16 | 892–971 | Not Predicted | Protein of unknown function |
| 9 | Fusion Glycoprotein F0 | 910–935 | Not Predicted | Induces fusion of viral and cellular membranes leading to delivery of the nucleocapsid into the cytoplasm |
| 10 | BIG1 | Not predicted | 1–3 | NA |
| 11 | Cysteine-rich Domain | 1217–1236 | 1235–1254 | Membrane fusion |