Table 1. Parameters describing the expected number of photons scattered into each pixel.

κi	Kahn polarization factor
r e	Classical electron radius
Js(λ)	Fluence (photons/area) at photon wavelength λ during shot s
Δh i,j,s	Ewald offset of pixel i for scattering from mosaic domain j during shot s, i.e. the residual between the fractional Miller index and the integer Miller index h = h, k, l
I 0(Δh i,j,s, m)	The interference function arising from the diffraction of the crystal lattice
ΔΩi	The solid angle subtended by the pixel
Zs	Dimensionless per-shot scale factor accounting for variations in exposed crystal volume for each shot. This represents the total number of mosaic domains in the crystal
m	Dimensionless quantity such that m 3 specifies the number of unit cells within each mosaic domain. For the synthetic data, we let m = 10, hence we used mosaic blocks consisting of 1000 unit cells
|F h|	Structure factor amplitude of the protein at Miller index h = h, k, l
λ	Photon wavelength
U j,s	Misseting matrix of mosaic domain j for the crystal from shot s
B	Direct space unit cell matrix for each crystal (same unit cell for each crystal)
Nj	Number of mosaic domains modeling texture. For the synthetic data, we let Nj = 100
q i(λ)	Momentum transfer vector at pixel i for photons of wavelength λ