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. 2020 Oct 22;11:591778. doi: 10.3389/fmicb.2020.591778

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Copyright © 2020 Lotke, Schneeweiß, Pietrek, Günther, Grundhoff, Weidner-Glunde and Schulz.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Brd/BET-mediated chromatin association of mLANA. ChIP-Seq was performed in A20-GFP, A20-mLANA WT, and A20-mLANA 3A cells that were treated with doxycycline at a final concentration of 1 μg/ml for 48 h. (A) Frequency distribution histograms of mLANA WT or mLANA 3A enriched regions relative to their distance from the TSS in bins of 200 bp (left), global normalized average fold enrichment profiles for mLANA WT or mLANA 3A in the vicinity of all cellular TSS in bins of 10 bp (center) and global normalized average fold enrichment profiles for mLANA WT or mLANA 3A on the meta-gene of 3 kbp (right). (B) ChIP-qPCR for mLANA WT and mLANA 3A mutant at the TSS of Rcan3 and Tm2D1. Bars represent mean ± SD. ***p < 0.001.