Figure 4.

The interaction of IL-25 and metastasis-related proteins. To interpret the confidence view, stronger associations are represented by the thicker lines. Protein-protein interactions are shown in solid lines. In our study, highly confident interaction was focused with a score >0.7. Filtering interactions network was according to transcription factor (in bold oval; NF-κB), transforming growth factor (in bold oval; TGF-β receptor 1) and metastasis-associated proteins (dashed oval; IL-25, SMAD 2, SNAI 1) were predicted by STITCH Version 5.0 (http://stitch.embl.de). IL-25 is associated with SMAD2, nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB), transforming growth factor beta (TGF-β1), and snail homolog 1 (Drosophila; SNAI1).