Table 1.
HAT and HDAC mediating the acetylation of repair proteins and exact lysine sites.
| Biological process | Protein | HAT | Modified lysine site | Function | HDAC | Modified lysine site | Function |
|---|---|---|---|---|---|---|---|
| MMR | MSH2 | HBO1 | DNA MMR activity | HDAC6, HDAC10 | 845, 847, 871, 892,73 | Self-stability/MutSα complex formation | |
| MLH1 | p300 | 33, 241 | MutSα-MutLα complex assemble | HDAC6 | 33, 241 | MutSα-MutLα complex assemble | |
| MSH6 | HDAC1 | ||||||
| BER | TDG | CBP, p300 | CBP release/recruit APE | CBP release/recruit APE | |||
| OGG1 | p300 | 338, 341 | Self-activity | SIRT3 | Mitochondrial genome integrity telomeres stability | ||
| NEIL2 | p300 | 49, 150, 153, 154 | Enzymatic activity | ||||
| APE1 | p300 | 6, 7, 27, 31, 32, 35, | Telomeres stability | SIRT1, HDAC1 | 27, 31, 32, 35 | ||
| NER | DDB1 | p300, CBP | 1,067 | SIRT7 | Interaction with CULA4 | ||
| DDB2 | 278 | ||||||
| XPA | CBP | 215 | Interaction with RPA32 | SIRT1, HDAC1 | 63, 67, 215 | Interaction with ATR, RPA, RPA32 | |
| XPG | p300, CBP, PCNA | Chromatin interaction | |||||
| HR | ATM | TIP60 | Autophosphorylation/self-activity | SIRT7 | Deactivation | ||
| NBS1 | P300 | SIRT1 | HR repair deficiency | ||||
| RAD51 | SIRT1, HDAC4, SIRT2, HDAC2 | Expression/HR repair deficiency | |||||
| EXO1 | |||||||
| CtIP | HDAC3 | DNA end resection/degradation | |||||
| CCAR2 | hMOF | 112, 215 | Protein interaction | SIRT1 | 112, 215 | ||
| BRG | SIRT1 | 1,029, 1,033 | ATPase activity | ||||
| RAD52 | p300, CBP | Dissociation from the DSBs | SIRT1, SIRT3 | dissociation from the DSBs | |||
| NHEJ | DNA-PKcs | 3,241, 3,260 | Repair efficiency | ||||
| KU70 | CBP | DNA binding/repair activity/protein interaction with Bax | SIRT1, HDAC6, SIRT6 | Repair capacity/protein interaction with Bax/apoptosis | |||
| New DNA fragments synthesis | PARP1 | p300, CBP, NAT10 | 498, 505, 508, 521, 524, 949 | Transcriptional coactivator activity/self-activity/ interaction with DNA/stability | SIRT1 | Cell death | |
| RPA1 | PCAF and GCN5 | 163 | Interaction with XPA | HDAC6,SIRT1 | Interaction with XPA | ||
| PCNA | p300/CBP, Eco1 | 13, 14, 77, 80, 248, 20 | Interaction with DNA Polδ and Polβ/sliding on DNA | ||||
| hSSB1 | p300 | 94 | p21 transcription | ||||
| DNA polβ | p300 | 72 | dRP-lyase activity | ||||
| DNA Polι | p300, CBP | 550 | Unclear | ||||
| FEN1 | p300 | Self-activity/DNA binding homodimerization/nuclear translocation | |||||
| Nucleotide synthesis | RRM2 | HAT7 | 95 | SIRT2 | 95 | Homodimerization | |
| Protein synthesis | TyrRS | PCAF | 244 | SIRT1 | 244 | Nuclear translocation |