Table 2.

Subgroup analysis for treatment duration.

Subgroups	Studies	No. ofParticipants (nE/nC)	Effects model	Pooled effect	95% Cl	P value
CER
Treatment duration (5-8 days)	14	1180/1044	Fixed	RR 1.16	1.16, 1.21	<0.00001
Treatment duration (14 days)	7	603/598	Fixed	RR 1.20	1.09, 1.31	<0.00001
Total	21	1783/1642	Fixed	RR 1.17	1.13, 1.22	<0.00001
Test for subgroup differences: Chi2 = 0.31, df=1 (P=0.58), I2 = 0%
RTC
Treatment duration (5-8 days)	12	1097/961	Random	MD -1.74	-2.14, -1.33	<0.00001
Treatment duration (14 days)	6	556/552	Random	MD -2.35	-3.09, -1.61	<0.00001
Total	18	1653/1513	Random	MD -1.92	-2.23, -1.51	<0.00001
Test for subgroup differences: Chi2 = 2.03, df=1 (P=0.15), I2 = 50.7%
RTR
Treatment duration (5-8 days)	11	1051/918	Random	MD -1.52	-1.99, -1.05	<0.00001
Treatment duration (14 days)	3	392/390	Random	MD -2.31	-3.52, -1.09	0.0002
Total	14	1443/1308	Random	MD -1.68	-2.27. -1.10	<0.00001
Test for subgroup differences: Chi2 = 1.40, df=1 (P=0.24), I2 = 28.5%
RTF
Treatment duration (5-8 days)	8	556/552	Random	MD -1.35	-1.85, -0.84	<0.00001
Treatment duration (14 days)	3	384/383	Random	MD -1.96	-2.05, -1.86	<0.00001
Total	11	946/935	Random	MD -1.46	-1.92, -1.00	<0.00001

Test for subgroup differences: Chi² = 5.40, df=1 (P=0.02), I² = 81.5%.