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. 2020 Oct 22;10:1776. doi: 10.3389/fonc.2020.01776

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Copyright © 2020 Sánchez-Alvarez, De Francesco, Fiorillo, Sotgia and Lisanti.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Mitochondrial fission factor (MFF) reduces mitochondrial respiration. The metabolic profile of stably transduced MCF7 cells harboring MFF (MCF-MFF) and the respective empty-vector (MCF-7 Control) was examined using the Seahorse XFe96 analyzer. (A) Oxygen consumption rate (OCR) is significantly reduced in cells transduced with MFF as compared to control cells. (B–F) Significant reductions in respiration (basal and maximal), proton leak, ATP levels and non-mitochondrial derived OCR were observed in MCF7 cells transduced with MFF as compared to the control cells. At least six replicates were performed in each experiment. Results are the average of the mean of three independent experiments and are expressed as percentages normalized to the control ± SEM. *p < 0.05, **p < 0.01.