TABLE 3.
Gene ontology analysis of differentially expressed genes in STAD.
| Expression | Category | Term | Count | P-value | FDR |
| Upregulated | GOTERM_BP_DIRECT | GO:0007155∼cell adhesion | 7 | 8.38E-07 | 0.001059856 |
| GOTERM_BP_DIRECT | GO:0035987∼endodermal cell differentiation | 4 | 1.68E-05 | 0.021196552 | |
| GOTERM_BP_DIRECT | GO:0030199∼collagen fibril organization | 4 | 2.35E-05 | 0.029671995 | |
| GOTERM_BP_DIRECT | GO:0071230∼cellular response to amino acid stimulus | 3 | 0.003303913 | 4.09798155 | |
| GOTERM_BP_DIRECT | GO:()001501-skeletal system development | 3 | 0.004586779 | 5.647054851 | |
| GOTERM_CC_DIRECT | GO:0005581-collagen trimer | 7 | 1.31E-09 | 135E-06 | |
| GOTERM_CC_DIRECT | GO:0005578∼proteinaceous extracellular matrix | 8 | 5.16E-08 | 5.29E-05 | |
| GOTERM_CC_DIRECT | GO:0005615∼extracellular space | 12 | 1.21E-06 | 0.001236783 | |
| GOTERM_CC_DIRECT | GO:0070062∼extrdcellular exosome | 12 | 0.002224851 | 2.258522618 | |
| GOTERM_CC_DIRECT | GO:0005576∼extracellular region | 6 | 0.00306613 | 3.100466564 | |
| GOTERM_MF_DIRECT | GO:0042802∼identical protein binding | 4 | 0.002087486 | 1.983628784 | |
| GOTERM_MF_DIRECT | GO:0005201-extracellular matrix structural constituent | 3 | 0.002236986 | 2.124328943 | |
| GOTERM_MF_DIRECT | GO:0005515∼protein binding | 4 | 0.003812268 | 3.59592875 | |
| GOTERM_MF_DIRECT | GO:0005509∼calcium ion binding | 6 | 0.003982864 | 3.75410086 | |
| GOTERM_MF_DIRECT | GO:0048407∼platelet-derived growth factor binding | 2 | 0.005716885 | 5.348701785 | |
| Downregulated | GOTERM_BP_DIRECT | GO:0007586∼digestion | 8 | 6.67E-09 | 9.09E-06 |
| GOTERM_BP_DIRECT | GO:0006081∼cellular aldehyde metabolic process | 4 | 1.07E-05 | 0.014571778 | |
| GOTERM_BP_DIRECT | GO:0006805∼xenobiotic metabolic process | 6 | 1.69E-05 | 0.023039718 | |
| GOTERM_BP_DIRECT | GO:(X)55114∼oxidation-reduction process | 12 | 2.71 E-05 | 0.036936867 | |
| GOTERM_BP_DIRECT | GO:0010107∼potassium ion import | 4 | 2.02E-04 | 0.27485333 | |
| GOTERM_CC_DIRECT | GO:0005615∼extracellular space | 20 | 1.49E-06 | 0.001568694 | |
| GOTERM_CC_DIRECT | GO:0016324∼apical plasma membrane | 6 | 0.006968923 | 7.094816498 | |
| GOTERM_CC_DIRECT | GO:0070062∼extracellular exosome | 21 | 0.008418185 | 8.511744286 | |
| GOTERM_CC_DIRECT | GO:0031225∼anchored component of membrane | 4 | 0.011341676 | 11.31066102 | |
| GOTERM_CC_DIRECT | GO:0005764∼lysosome | 5 | 0.014100077 | 13.88022987 | |
| GOTERM_MF_DIRECT | GO:0005242∼inward rectifier potassium channel activity | 3 | 0.002416557 | 2.873134203 | |
| GOTERM_MF_DIRECT | GO:0018479∼benzaldehyde dehydrogenase (NAD +) activity | 2 | 0.007332264 | 8.48537793 | |
| GOTERM_MF_DIRECT | GO:0008900∼hydrogen:potassium-exchanging ATPase activity | 2 | 0.010978534 | 12.45446088 | |
| GOTERM_MF_DIRECT | GO:0001758∼retinal dehydrogenase activity | 2 | 0.025432302 | 26.68434583 | |
| GOTERM_MF_DIRECT | GO:0015280∼ligand-gated sodium channel activity | 2 | 0.029013148 | 29.86504406 |