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The central node genes in the PPI network were identified based on the filtering degree ≥10.
| Node gene | Degree |
| COL1A1 | 24 |
| COL1A2 | 21 |
| FN1 | 20 |
| COL5A2 | 18 |
| BGN | 16 |
| COL6A3 | 16 |
| COL12A1 | 15 |
| THBS2 | 15 |
| CDH11 | 12 |
| SERPINH1 | 11 |
| COL10A1 | 11 |
| TFF2 | 11 |
| ASPN | 11 |
| MUC5AC | 10 |
