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V̇o2max is one of the best predictors of morbidity and mortality
Regular aerobic exercise improves V̇o2max at least partially through its benefits on mitochondria. The effect of metformin and statins on this mitochondrial adaptation to exercise may be dictated by the health or disease of the individual. There is limited evidence that pharmaceutical treatment, and, conversely, positive exercise adaptations, can change the overall comfort of exercise, thus impacting adherence.
