Fig. 8.

C-C motif chemokine ligand 2 (CCL2) expression in cisplatin-induced kidney injury. Correlations of Ccl2 mRNA expression with body weight loss (A), blood urea nitrogen (BUN) (B), neutrophil gelatinase-associated lipocalin (NGAL) (C), and kidney injury molecule-1 (Kim-1) mRNA (D) in C57BL/6 mice treated with repeated administration of 9 mg/kg cisplatin. Correlations were found using a linear regression model with significance determined as P < 0.05. D: urinary CCL2 in C57BL/6 mice treated with repeated administration of 9 mg/kg cisplatin. An ELISA was performed on 50 μL of undiluted urine from vehicle- and cisplatin-treated mice. Vehicle-treated mice had no detectable signal. Statistical analysis was determined by one-way ANOVA. **P < 0.01.