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. 2020 Aug 17;319(4):F647–F653. doi: 10.1152/ajprenal.00112.2020

Fig. 4.

Fig. 4.

Effect of intramedullary (pro)renin receptor inhibition on fluid homeostasis in DOCA-salt (DOCA) rats. In a separate experiment, following 2-wk treatment with DOCA and PRO20, rats were acclimatized in metabolic cages. Day 14 water intake (A) and urine volume (B) were measured. Plasma samples were harvested and subjected to analysis of hematocrit (Hct; C). n = 5 animals/group. CTR, control; IM PRO20, intramedullary PRO20 infusion; IV PRO20, intravenous PRO20 infusion. Statistical significance was determined using one-way ANOVA with the Bonferroni test for multiple comparisons, and P values are indicated. Data are means ± SE.