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. 2020 Oct 22;12:576627. doi: 10.3389/fnagi.2020.576627

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Copyright © 2020 Behfar, Behfar, von Reutern, Richter, Dronse, Fassbender, Fink and Onur.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Increase and decrease of degree centrality in a comparison of young HC, senior HC, and MCI. (A) Young HC vs. senior HC and MCI contrast, in which blue shade circles represent a significant increase, and red shade circles represent a significant decrease of DC in Senior HC and MCI subjects compared to young HC (p < 0.05, FDR-corrected). (B) Senior HC vs. MCI contrast, in which blue shade circles represent a significant increase, and red shade circles represent a significant decrease of DC in MCI subjects compared to senior HC (p < 0.05, FDR-corrected). The significant ROIs are according to labeling by the Brainnetome atlas (I) PrG_L_6_2, (II) SPL_R_5_1, (III) PrG_R_6_2, and (IV) MFG_R_7_7. (C) All four compensatory ROIs stem from the two intergroup contrasts.