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Endothelin-1 (ET-1) excretion is increased in female systemic lupus erythematosus (SLE) mice fed a 4% NaCl diet at 34 wk of age. SLE mice fed a 4% NaCl diet had a significant increase in ET-1 excretion compared with those fed a 0.4% NaCl diet by 34 wk of age; *P = 0.0002, per 2-tailed, unpaired t test. n = 12 (0.4% NaCl) and n = 9 (4% NaCl). Error bars represent SE.
