Table 3.
Single variable conditional logistic regression model for risk factors associated with severe COVID-19 on admission
| Variables | Crude odds ratio (95% CI) | P value | Adjusted odds ratioa (95% CI) | P value |
|---|---|---|---|---|
| HR, times per min (>89.5 vs. <89.5) | 1.739 (1.055–2.865) | 0.030 | 1.799 (1.087–2.977) | 0.022 |
| RR, breaths per min (>20.5 vs. <20.5) | 1.722 (1.063–2.791) | 0.027 | 1.744 (1.074–2.830) | 0.024 |
| SpO2, % (<95.5 vs. >95.5) | 2.369 (1.427–3.935) | 0.001 | 2.359 (1.419–3.923) | 0.001 |
| Neutrophil, × 109/l (>3.89 vs. <3.89) | 1.773 (1.088–2.889) | 0.022 | 1.779 (1.091–2.900) | 0.021 |
| Lymphocyte × 109/l (<0.97 vs. >0.97) | 1.434 (1.434–3.806) | 0.001 | 2.319 (1.407–3.823) | 0.001 |
| Albumin, g/l (<36.7 vs. >36.7) | 2.149 (1.273–3.626) | 0.004 | 2.196 (1.299–3.712) | 0.003 |
| LDH, U/l (>290.0 vs. <290.0) | 1.825 (1.126–2.959) | 0.015 | 1.911 (1.155–3.161) | 0.012 |
| CRP, mg/l (>34.8 vs. <34.8) | 2.441 (1.474–4.042) | 0.001 | 2.651 (1.559–4.506) | <0.0001 |
| PCT, ng/ml (>0.11 vs. <0.11) | 1.732 (0.991–3.028) | 0.054 | 2.022 (1.043–3.920) | 0.037 |
| Fibrinogen, g/l (>4.97 vs. <4.97) | 2.503 (1.330–4.708) | 0.004 | 2.668 (1.362–5.226) | 0.004 |
| hs-cTnI, pg/ml (>2.25 vs. <2.25) | 1.962 (1.053–3.655) | 0.034 | 2.185 (1.137–4.199) | 0.019 |
| IL-6, pg/ml (>11.94 vs. <11.94) | 1.912 (0.876–4.177) | 0.104 | 2.032 (0.882–4.683) | 0.096 |
| IL-10, pg/ml (>5.1 vs. <5.1) | 2.635 (1.207–5.754) | 0.015 | 2.724 (1.213–6.117) | 0.015 |
| NT-proBNP, pg/ml (>189.5 vs. <189.5) | 1.949 (1.062–3.575) | 0.031 | 1.939 (1.054–3.566) | 0.033 |
HR, heart rate; RR, respiratory rate; SpO2, peripheral oxygen saturation; LDH, lactate dehydrogenase; CRP, C-reactive protein; PCT, procalcitonin; hs-cTnI, hypersensitive cardiac troponin I; NT-proBNP, N terminal pro B type natriuretic peptide.
a
Adjusted for age and sex. All variables were classified into sub-groups with a cutoff value in the ROC curve analysis.