Table 5. Enrichment of DNA repair and stress-responsive genes among AFB1 resistant genes.
| GO Biological Process | Yeasta | AFB1 Resistant Genes | Expectedb | Foldc Enrichment | P valued. | Significancee. |
|---|---|---|---|---|---|---|
| Cellular response to DNA damage stimulus | 338 | 22 | 5 | 4.5 | 1.20E-06 | + |
| DNA synthesis involved in DNA repair | 20 | 7 | <1 | >7 | 8.00E-05 | + |
| Translesion synthesis | 18 | 7 | <1 | >7 | 4.42E-05 | + |
| DNA repair | 293 | 19 | 4 | 4.5 | 2.47E-05 | + |
| Cellular response to stress | 711 | 29 | 9.4 | 3.1 | 1.48E-04 | + |
| Postreplication repair | 30 | 7 | <1 | >7 | 8.35E-04 | + |
| Double-strand break repair | 136 | 11 | 2 | 5.6 | 5.97 E-03 | + |
| DNA biosynthetic process | 98 | 9 | 1.4 | 6.4 | 1.58 E-02 | + |
a
Number of total yeast genes in GO group based on reference list of 6026.
b
Number of expected genes among initial set of 79 ORFs based on reference list of 6026 genes; fractional values less than 1 were designated as <1.
c
Fold enrichment is the ratio of the number of AFB1 resistant genes identified to the expected number.
d
Displaying only results for Bonferroni-corrected probabilities, P < 0.05.
e
Significance indicated by “+”