Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2020 Sep 8;10(11):4049–4062. doi: 10.1534/g3.120.401718

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2020 Ghosh et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

PMC Copyright notice

Pathway-level overlap in tissue (A) and isolated cellular level (B) samples: Argenase pathway, Th1/Th2 signaling, VEGF signaling and Inflammation and Aryl hydrocarbon pathways were most predominant on blood, biopsy, airway epithelial and nasal samples respectively. EIF2 signaling was relevant for macrophages and proximal fibroblasts, while lymphocyte extravasation (adhesion and diapedesis), IL6 pathway and IL-8 signaling pathways were very relevant for CD4+, distal lung fibroblasts and CD8+ cells respectively. In addition, Glucocorticoid Receptor Signaling, Clathrin-mediated Endocytosis Signaling were top significantly enriched pathways in all tissue types. IL-1beta and ERK signaling pathways were common across a wide range of tissue types. Chemokine signaling (in nasal epithelium) were the most significant pathways.