Table 3. Top 10 overrepresented orthologs in the Hydra viridissima genome and comparison of their gene number in the other cnidarian genomes. A. Orthologs enriched in the Hydra viridissima genome. B Orthologs enriched in Hydra species.

A. Ortholog ID	Hvir	Hvul	Ch	Aa	Mv	Nv	Ad	Chi-test*	Annotation
OG0000023	152	51	30	19	0	0	0	8E-128	Nod-like receptor like
OG0000049	98	48	11	4	15	26	1	2E-58	Uncharacterized protein
OG0000100	73	29	0	0	0	1	0	3E-79	Uncharacterized protein
OG0000191	29	13	11	0	0	8	0	3E-17	Uncharacterized protein
OG0000159	24	4	0	8	2	0	0	7E-21	Uncharacterized protein
OG0000602	23	6	2	0	0	0	0	3E-24	Uncharacterized protein
OG0000766	23	1	1	0	0	0	1	2E-30	TIR-only protein
OG0000525	19	8	1	0	0	0	0	2E-18	Uncharacterized protein
OG0001051	18	1	0	0	0	0	0	1E-25	Uncharacterized protein
OG0000975	14	6	2	0	0	0	1	1E-11	DDE superfamily endonuclease

B. Ortholog ID	Hvir	Hvul	Ch	Aa	Mv	Nv	Ad	Chi-test*	Annotation
OG0000006	299	339	28	21	29	3	7	2E-262	HTH domain containing transposase
OG0000018	204	130	9	14	0	1	0	5E-194	ATP-dependent DNA helicase PIF1-like
OG0000015	185	128	46	14	1	0	45	6E-122	TPR containing
OG0000008	184	360	15	9	5	1	3	2E-249	DDE superfamily endonuclease
OG0000027	166	144	2	4	2	3	2	8E-163	Uncharacterized protein
OG0000036	95	154	1	1	7	1	1	4E-114	zinc finger domain containing transposase
OG0000010	82	352	12	38	19	11	2	4E-201	Uncharacterized protein
OG0000073	77	39	19	1	0	0	0	2E-66	Uncharacterized protein
OG0000100	73	29	0	0	0	1	0	5E-81	Uncharacterized protein
OG0000093	61	44	0	1	8	2	0	1E-52	Uncharacterized protein

Hvir: Hydra viridissima A99, Hvul: Hydra vulgaris (Hydra2.0), Ch: Clytia hemisphaerica, Mv: Morbakka virulenta, Aa: Aurelia aurita, Nv, Nematostella vectensis, Ad: Acropora digitifera, *Chi-test: evalue of Chi-square test.