Figure 2.

Congenic gene trap lines support B6 sensitivity to reduced Zfp423 function. (A) Gene trap (gt) homozygotes are recovered with reduced frequency on B6 but not BALB/c congenic background. (B) Surviving B6-gene trap homozygotes were frequently judged ataxic prior to genotyping, while BALB/c-gene trap homozygotes were not. (C) Parasagittal sections through cerebellar vermis showed reduced area in gene trap homozygotes compared to littermates, but the trend toward larger difference on B6 was not significant at alpha = 0.05 level for a two-tailed test. (D) A subset of B6 gene trap homozygotes were hydrocephalic, while none of the other mice were.