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. 2020 Sep 23;10(11):4241–4247. doi: 10.1534/g3.120.401720

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Copyright © 2020 Alcaraz et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Linkage mapping supports a survival locus on Chr. 5. (A) Chi-squared tests for expected 25% B6-homozygous fraction (1 degree of freedom) in 370 F2 progeny from a BALB/c x B6 intercross. Chromosome 8 is omitted as constrained by Zfp423 requirement. (B) Chi-squared test for 50% homozygotes in 133 backcross progeny. (C) 2-part model for survival (latency) up to P60 for the intercross progeny in (A). Lod.p.mu is the combined lod score for penetrance (lod.p) and severity (lod.mu) using log survival from entry at P12 to endpoint at P60 as a quantitative phenotype. (D) 2-part model applied to the backcross progeny in (B). (E) Marker effect plots for survival up to postnatal day (d) 60 in the intercross. (F) Effect plots for the same markers in the backcross.