Table 1. Datasets used in this study. UKB, UK Biobank; WHI, Women’s Health Initiative; JHS, Jackson Heart Study; HRS, Health and Retirement Study; CI, bootstrap 95% confidence intervals.
| Dataset | Ancestry | Na | Total number of SNPSb | Number of SNPs in PRSc | Partial-R2 (CI, %) | European Ancestry (%) |
|---|---|---|---|---|---|---|
| UKB European subset (UKB_eur) | European | 9,998d | 685,475 | 6,052 | 22.4 (20.8-24) | 100 |
| HRS European (HRS_eur) | European American | 10,159 (10,123) | 1,515,431 (10,118,786) | 7,117 (9,724) | 15.6 (14.4-16.9) | 100 |
| UKB admixed African (UKB_afr) | African + European | 8,700 (8,696) | 685,475 (13,279,553) | 6,049 (10,577) | 4.1 (3.2-4.9) | 13.1 |
| WHI (WHI_afr) | African American | 6,863 | 741,983 | 5,744 | 3.6 (2.8-4.5) | 22.7 |
| JHS (JHS_afr) | African American | 1,773 | 702,685 | 5,676 | 3.8 (2.2-5.7) | 17.7 |
| HRS admixed African HRS_afr | African American | 2,251 (2,241) | 1,511,742 (10,118,786) | 7,101 (9,724) | 3.1 (1.9-4.6) | 17.5 |
a
number of individuals;
b
number of SNPs in the intersection between genotyped (or imputed) SNPs and SNPs from the height GWAS that passed our filters;
c
SNPs clumped in 100 Kb windows and with P < 0.0005;
a, b,c
number of individuals and SNPs in imputed set in parentheses; d, randomly selected from the entire European component of the cohort.