Table 3.
Significantly differentially expressed gene sets in skeletal muscle from women with PCOS compared with controls (GSEA, q ≦0.25).
| Gene set name | Size | ES | NES | p | q |
|---|---|---|---|---|---|
| Upregulated enriched gene sets | |||||
| MYC TARGETS V1 | 165 | 0.37 | 1.71 | 0.000 | 0.023 |
| SPERMATOGENESIS | 46 | 0.45 | 1.71 | 0.000 | 0.043 |
| G2M CHECKPOINT | 99 | 0.34 | 1.47 | 0.019 | 0.109 |
| HEME METABOLISM | 124 | 0.32 | 1.43 | 0.013 | 0.124 |
| MYOGENESIS | 163 | 0.29 | 1.34 | 0.035 | 0.20 |
| Downregulated enriched gene sets | |||||
| INTERFERON ALPHA RESPONSE | 67 | −0.57 | −2.45 | 0.000 | 0.000 |
| INTERFERON GAMMA RESPONSE | 127 | −0.44 | −2.14 | 0.000 | 0.001 |
| CHOLESTEROL HOMEOSTASIS | 50 | −0.49 | −2.00 | 0.000 | 0.001 |
| XENOBIOTIC METABOLISM | 117 | −0.42 | −2.00 | 0.000 | 0.001 |
| COAGULATION | 66 | −0.45 | −1.94 | 0.000 | 0.001 |
| EPITHELIAL MESENCHYMAL TRANSITION | 130 | −0.39 | −1.89 | 0.000 | 0.002 |
| APOPTOSIS | 114 | −0.32 | −1.54 | 0.003 | 0.048 |
| IL2 STAT5 SIGNALING | 117 | −0.32 | −1.52 | 0.000 | 0.047 |
| APICAL JUNCTION | 111 | −0.31 | −1.51 | 0.003 | 0.047 |
| COMPLEMENT | 106 | −0.31 | −1.45 | 0.008 | 0.067 |
| HEDGEHOG SIGNALING | 16 | −0.43 | −1.31 | 0.125 | 0.19 |
| INFLAMMATORY RESPONSE | 86 | −0.29 | −1.30 | 0.070 | 0.20 |
| HYPOXIA | 134 | −0.26 | −1.27 | 0.063 | 0.21 |
| TNFA SIGNALING VIA NFKB | 116 | −0.26 | −1.24 | 0.083 | 0.25 |
| P53 PATHWAY | 136 | −0.25 | −1.24 | 0.065 | 0.23 |
| ADIPOGENESIS | 164 | −0.24 | −1.23 | 0.078 | 0.22 |
| ALLOGRAFT REJECTION | 87 | −0.27 | −1.22 | 0.130 | 0.24 |
| IL6 JAK STAT3 SIGNALING | 40 | −0.31 | −1.20 | 0.192 | 0.25 |
| ANGIOGENESIS | 22 | −0.35 | −1.20 | 0.208 | 0.24 |
The enrichment score (ES) was calculated for each gene set, the primary outcome of GSEA. NES, Enrichment score normalized for differences in gene set size.