TABLE 3.
Antimicrobial non-susceptibility of Streptococcus pneumoniae from different age groups, 2002–2018.
| Agenta |
% of non-susceptible isolates |
P |
||||
| <17 y.o. | 18–64 y.o. | >65 y.o. | ||||
| n = 586 | n = 533 | n = 677 | <17 vs. 18–64 | 18–64 vs. >65 | <17 vs. >65 | |
| β-lactam | ||||||
| AMC (non-meningitis) | 22.0 | 21.2 | 16.8 | NS | NS | <0.05 |
| Cefepime (non-meningitis) | 24.1 | 23.3 | 23.9 | NS | NS | NS |
| (meningitis) | 66.9 | 54.3 | 57.7 | <0.01 | NS | <0.01 |
| Cefotaxime (non-meningitis) | 19.9 | 19.5 | 18.6 | NS | NS | NS |
| (meningitis) | 65.1 | 52.0 | 54.5 | <0.01 | NS | <0.01 |
| Ceftriaxone (non-meningitis) | 24.2 | 24.0 | 23.2 | NS | NS | NS |
| (meningitis) | 67.4 | 55.0 | 58.5 | <0.01 | NS | NS |
| Cefuroxime (oral) | 76.8 | 65.8 | 68.8 | <0.01 | NS | <0.01 |
| (parenteral) | 77.7 | 68.3 | 72.6 | <0.01 | NS | NS |
| Meropenem | 66.7 | 53.7 | 57.9 | <0.01 | NS | <0.01 |
| Penicillin (oral) | 87.0 | 74.3 | 79.6 | <0.01 | <0.05 | <0.01 |
| (parenteral, non-meningitis) | 34.4 | 30.9 | 30.2 | NS | NS | NS |
| (parenteral, meningitis) | 87.9 | 77.5 | 81.7 | <0.01 | NS | <0.01 |
| Non-β-lactam | ||||||
| Chloramphenicol | 37.7 | 36.8 | 40.0 | NS | NS | NS |
| Clindamycin | 73.9 | 73.7 | 71.1 | NS | NS | NS |
| Erythromycin | 96.1 | 91.4 | 92.0 | <0.01 | NS | <0.01 |
| Levofloxacin | 1.1 | 5.1 | 11.8 | <0.01 | <0.01 | <0.01 |
| Tetracycline | 94.7 | 94.2 | 93.8 | NS | NS | NS |
| TMP/SMX | 74.7 | 65.9 | 70.0 | <0.01 | NS | NS |
aAmoxicillin/clavulanate (AMC) was not tested in 2008 and clindamycin was not tested in 2002–2006. TMP/SMX, trimethoprim/sulfamethoxazole.