TABLE 4.
Antimicrobial non-susceptibility of major Streptococcus pneumoniae serotypes (in order of frequency), 2002–2018.
| Agenta |
% of non-susceptible isolates |
||||||||||||||
|
PCV7b |
PCV13 |
Non-PCV13 |
|||||||||||||
| 19F | 23F | 6B | 14 | 9V | 3 | 19A | 6A | 15A | 15B | 23A | 11A | 15C | 35B | 34 | |
| n = 337 | n = 292 | n = 210 | n = 136 | n = 42 | n = 129 | n = 102 | n = 56 | n = 64 | n = 64 | n = 56 | n = 44 | n = 29 | n = 25 | n = 25 | |
| β-lactam | |||||||||||||||
| AMC (non-meningitis) | 34.2 | 11.9 | 10.1 | 12.1 | 25.0 | 1.8 | 97.8 | 2.0 | 14.3 | 2.0 | 21.3 | 8.1 | 0 | 0 | 0 |
| Cefepime (non-meningitis) | 37.4 | 38.3 | 3.8 | 21.4 | 50.0 | 1.6 | 67.6 | 23.2 | 1.6 | 25.0 | 19.6 | 25.0 | 17.2 | 0 | 4.0 |
| (meningitis) | 86.7 | 87.0 | 60.5 | 69.8 | 90.5 | 1.6 | 99.0 | 55.3 | 11.0 | 48.4 | 21.4 | 38.6 | 65.5 | 36.0 | 16.0 |
| Cefotaxime (non-meningitis) | 31.2 | 31.2 | 0.5 | 14.7 | 38.1 | 1.6 | 62.8 | 16.1 | 1.6 | 23.4 | 17.9 | 9.0 | 17.2 | 0 | 4.0 |
| (meningitis) | 84.0 | 83.9 | 52.4 | 71.3 | 88.1 | 2.4 | 99.0 | 57.2 | 4.7 | 46.9 | 21.4 | 36.4 | 65.5 | 32.0 | 16.0 |
| Ceftriaxone (non-meningitis) | 37.7 | 37.7 | 1.4 | 19.9 | 40.5 | 1.6 | 71.6 | 26.8 | 3.1 | 31.3 | 19.6 | 22.7 | 34.5 | 0 | 8.0 |
| (meningitis) | 88.4 | 87.7 | 61.4 | 73.6 | 88.1 | 1.6 | 99.1 | 57.2 | 10.9 | 56.3 | 21.4 | 36.3 | 65.5 | 40.0 | 16.0 |
| Cefuroxime (oral) | 94.1 | 95.6 | 79.6 | 80.9 | 100 | 1.6 | 99.0 | 73.2 | 82.8 | 62.5 | 23.2 | 38.6 | 72.4 | 44.0 | 28.0 |
| (parenteral) | 95.3 | 96.9 | 83.3 | 84.6 | 100 | 9.4 | 99.0 | 73.2 | 85.9 | 62.5 | 23.2 | 38.6 | 72.4 | 44.0 | 28.0 |
| Meropenem | 86.0 | 82.2 | 43.8 | 69.9 | 95.2 | 1.6 | 99.0 | 55.4 | 68.8 | 56.3 | 21.4 | 36.3 | 69.0 | 36.0 | 16.0 |
| Penicillin (oral) | 99.7 | 97.3 | 92.9 | 96.3 | 100 | 1.6 | 100 | 83.9 | 87.5 | 85.9 | 73.2 | 38.6 | 96.6 | 68.0 | 28.0 |
| (parenteral, non-meningitis) | 58.4 | 45.2 | 10.5 | 33.8 | 50.0 | 0.8 | 90.2 | 25.0 | 6.2 | 25.0 | 17.9 | 27.3 | 24.1 | 0 | 4.0 |
| (parenteral, meningitis) | 99.7 | 97.3 | 92.9 | 96.3 | 100 | 1.6 | 100 | 83.9 | 87.5 | 85.9 | 91.1 | 38.7 | 96.6 | 68.0 | 28.0 |
| Non-β-lactam | |||||||||||||||
| Chloramphenicol | 19.3 | 72.6 | 40.0 | 35.3 | 31.0 | 76.7 | 1.0 | 62.5 | 10.9 | 64.1 | 8.9 | 13.6 | 72.4 | 12.0 | 12.0 |
| Clindamycin | 63.1 | 57.6 | 47.7 | 83.7 | 100 | 80.0 | 98.0 | 66.7 | 98.2 | 80.5 | 93.3 | 90.9 | 85.7 | 50.0 | 37.5 |
| Erythromycin | 99.1 | 96.9 | 98.6 | 95.6 | 97.6 | 82.2 | 100 | 89.3 | 95.3 | 92.2 | 96.4 | 97.7 | 100 | 84.0 | 52.0 |
| Levofloxacin | 10.1 | 11.0 | 2.4 | 5.1 | 33.3 | 2.3 | 0 | 1.8 | 3.1 | 3.1 | 0 | 0 | 6.9 | 0 | 4.0 |
| Tetracycline | 97.9 | 95.2 | 98.6 | 91.2 | 90.5 | 90.0 | 96.1 | 92.9 | 100 | 95.3 | 96.4 | 97.7 | 100 | 68.0 | 72.0 |
| TMP/SMX | 97.1 | 85.9 | 96.6 | 57.4 | 100 | 1.6 | 99.0 | 71.5 | 6.2 | 71.9 | 23.2 | 84.1 | 72.4 | 44.0 | 28.0 |
aAmoxicillin/clavulanate (AMC) was not tested in 2008 and clindamycin was not tested in 2002–2006. TMP/SMX, trimethoprim/sulfamethoxazole. b PCV7 serotypes are included in PCV13.