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. 2020 Oct 22;11:587709. doi: 10.3389/fphys.2020.587709

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Copyright © 2020 Sutanto and Heijman.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Action potential and Ca²⁺-transient alternans at 4 Hz pacing. The upper panels exemplify the AP and Ca²⁺-transient alternans at 4 Hz pacing in non-treated, CQ alone, and AZM alone groups. The application of 1 μM ISO abolishes the alternans, as shown in the lower panels. AP, action potential; AZM, azithromycin; Ctl, control; CQ, chloroquine; ISO, isoproterenol.