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. 2020 Oct 22;11:587709. doi: 10.3389/fphys.2020.587709

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Copyright © 2020 Sutanto and Heijman.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The impact of I_Ks and I_Ca,L phosphorylation on the action potential of canine ventricular epicardium in the presence of CQ and AZM. The effect of CQ 5 μM in combination with AZM 20 μM in the presence of ISO-induced I_Ks and I_Ca,L phosphorylation is shown in solid green lines. The green dashed lines represent the effect of CQ 5 μM in combination with AZM 20 μM in the absence of ISO-induced I_Ks and I_Ca,L phosphorylation.