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. 2020 Oct 22;10:552907. doi: 10.3389/fonc.2020.552907

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Copyright © 2020 Chen, Wang, Xu, Xu, Chen, Wang, Huang, Wen and Fang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effect of SNHG1 on the growth of subcutaneous tumors in nude mice by regulating EZH2. (A) Images of xenograft tumor sizes of each group. (B) The tumor volume growth curves after the injection in each group. (C) The tumor weight after the injection in each group. (D) Ki67 immunostaining of the animal tumor specimens from three groups. (E) Western blot to detect autophagy-related protein LC3-II, Beclin-1 and P62 protein expression levels in the animal tumor tissue transfected with NC, si-SNHG1, and si-SNHG1 + EZH2. (F) Western blot to detect Wnt/β-catenin signaling pathway-related protein Wnt1, β-catenin, c-myc and cyclin D1 protein expression levels. (G) Western blot to detect PI3K/AKT/mTOR signaling pathway-related protein p-PI3K, p-AKT, p-mTOR and p-p70S6K protein expression levels. **P < 0.01 vs. NC group; ^##P < 0.01 vs. si-SNHG1 + con group.