TABLE 4.
Comparison of the predictive performance of PRS according to different SNP sets.
| Top N SNPs included for PRS calculation |
Mean PRS |
AUC [95% CI] | Maximum Youden’s Index (J) | Sensitivity | Specificity | Improvement in AUC (p)* | |
| Case | Control | ||||||
| 4 | 0.131 | 0.16 | 0.637 [0.582–0.692] | 0.221 | 0.543 | 0.677 | Ref |
| 5 | 0.139 | 0.163 | 0.628 [0.574–0.683] | 0.227 | 0.534 | 0.694 | − 0.009 (0.406) |
| 6 | 0.135 | 0.155 | 0.624 [0.569–0.678] | 0.208 | 0.498 | 0.710 | − 0.013 (0.360) |
| 3 | 0.151 | 0.181 | 0.607 [0.552–0.662] | 0.171 | 0.607 | 0.565 | − 0.03 (0.005) |
*The ROC curves were compared with the reference ROC curve using DeLong’s test.