Figure 3.

Comparison about the distribution of the concatenated multi-level multi-type W-score feature set among different disease groups: (A) NC(ADNI) vs. NC(FTDNI); (B) NC vs. AD in ADNI database; (C) NC vs. FTD in FTDNI database; and (D) FTD vs. AD. (A) No statistical difference was shown when comparing the W-scores of the Healthy Control subjects between the ADNI and FTDNI, confirming no database-specific biases remained in the input w-score feature of the normative group. (B) Similar level of significant differences were shown when comparing the NC and AD subjects in the ADNI database, or (C) When comparing the NC and the FTD subjects in the FTDBI database, indicating similarity between the AD and FTD group. (D) When comparing the FTD and AD group alone, significant differences were observed in both the volume-based and thickness-based features, indicating discrepancy between these two types of Dementia subtypes which can be utilized to achieve potential differential diagnosis. Unpaired t-test were performed for each pair of the comparison, with multiple comparison corrected by setting false discovery rate (FDR) = 0.05.