Skip to main content
. 2020 Oct 22;7:585859. doi: 10.3389/fmed.2020.585859

Table 4.

Cox proportional hazard model for the primary end point in IgA nephropathy patients.

Risk factor Univariable Multivariable
HR (95% CI) p-value HR (95% CI) p-value
Gender
   Male 0.56 (0.34–0.93) 0.025 1.36 (0.62–2.98) 0.445
   Female 1 (Referent)
Hypertension 3.96 (2.39–6.56) <0.001 1.99 (1.16–3.42) 0.012
Urinary protein 1.05 (0.98–1.13) 0.192 1.08 (0.98–1.18) 0.109
Serum creatinine 1.03 (1.02–1.04) <0.001 1.02 (1.00–1.05) 0.024
eGFR 0.96 (0.95–0.97) <0.001 1.00 (0.99–1.01) 0.943
CKD 1 1 (Referent)
CKD 2 4.96 (2.41–10.21) <0.001 1.62 (0.64–4.11) 0.309
CKD3a 9.71 (4.66–20.24) <0.001 0.80 (0.20–3.26) 0.759
M1 6.14 (1.50–25.16) 0.012 3.19 (0.75–13.52) 0.116
E1 2.33 (1.00–5.41) 0.051 3.10 (1.14–8.42) 0.027
S1 2.32 (1.36–3.94) 0.002 1.51 (0.86–2.65) 0.155
T1/T2 8.87 (5.30–14.83) <0.001 3.34 (1.98–6.33) <0.001
C1/C2 1.41 (0.82–2.41) 0.213 0.81 (0.43–1.53) 0.521
Age 0.996 (0.97–1.02) 0.781
Serum albumin 0.99 (0.96–1.02) 0.507
NS 1.00 (0.55–1.85) 0.991

HR, hazard ratio; 95% CI, 95% confidence interval; eGFR, estimated glomerular filtration rate; CKD, chronic kidney disease; M, mesangial proliferation; E, endocapillary proliferation; S, segmental sclerosis; T, tubular atrophy/interstitial fibrosis; C, crescents.