Table 2. Multivariate Incidence Rate Ratios (IRRs) for Sebaceous Carcinoma Risk Among US Solid Organ Transplant Recipients.
Characteristic | Observed cases | Incidence rate per 100 000 person-years | Multivariate IRR (95% CI)a | P value |
---|---|---|---|---|
Sex | ||||
Female | 19 | 2.81 | [Reference] | <.001 |
Male | 83 | 7.90 | 2.46 (1.48-4.07) | |
Race/ethnicity | ||||
Non-Hispanic | .03 | |||
White | 80 | 7.15 | [Reference] | |
Black | 4 | 1.46 | 0.28 (0.10-0.77) | |
Hispanic | 13 | 5.35 | 1.09 (0.60-1.98) | |
Asian or Pacific Islander | 5 | 5.44 | 1.01 (0.40-2.51) | |
Age at transplant, y | ||||
0-44 | 13 | 1.80 | [Reference] | <.001b |
45-54 | 31 | 6.77 | 3.59 (1.87-6.90) | |
55-64 | 37 | 9.22 | 4.73 (2.47-9.05) | |
≥65 | 21 | 14.5 | 7.85 (3.85-16.0) | |
Transplanted organ | ||||
Kidney | 59 | 5.87 | [Reference] | .09 |
Liver | 13 | 3.43 | 0.52 (0.28-0.98) | |
Heart | 18 | 9.58 | 0.89 (0.51-1.56) | |
Lung | 8 | 13.3 | 1.87 (0.87-4.03) | |
Other or multiple | 4 | 4.21 | 0.92 (0.33-2.57) | |
Induction therapy with thymoglobulin | ||||
No | 73 | 5.30 | [Reference] | .009 |
Yes | 29 | 8.29 | 1.82 (1.16-2.86) | |
Posttransplant diagnosis of cutaneous squamous cell carcinoma | ||||
No | 83 | 4.89 | [Reference] | <.001 |
Yes | 19 | 65.6 | 4.60 (2.67-7.94) | |
Time since transplant, y | ||||
0-1.9 | 10 | 1.88 | [Reference] | <.001b |
2-4.9 | 30 | 5.47 | 2.86 (1.39-5.85) | |
5-9.9 | 35 | 7.62 | 4.04 (1.98-8.23) | |
≥10 | 27 | 14.4 | 8.40 (3.94-17.90) |
Multivariate model adjusted for variables listed in the table.
P value for trend.