Table 3. Characteristics of Patients With Sebaceous Carcinoma in the US General Population by Transplant Status.
| Characteristic | No. (%) | P valuea | |
|---|---|---|---|
| Nontransplant patients | Solid organ transplant recipients | ||
| Overall | 3585 (100.0) | 92 (100.0)b | |
| Sex | |||
| Female | 1691 (47.2) | 15 (16.3) | <.001 |
| Male | 1894 (52.8) | 77 (83.7) | |
| Race/ethnicity | |||
| Non-Hispanic | .18 | ||
| White | 2702 (75.4) | 62 (67.4) | |
| Black | 101 (2.8) | 1 (1.1) | |
| Hispanic | 144 (4.0) | 6 (6.5) | |
| Asian or Pacific Islander | 124 (3.5) | 5 (5.4) | |
| Unknown | 514 (14.3) | 18 (19.6) | |
| Age at diagnosis, y | |||
| 0-44 | 157 (4.4) | 4 (4.3) | <.001 |
| 45-54 | 385 (10.7) | 12 (13.0) | |
| 55-64 | 608 (17.0) | 33 (35.9) | |
| ≥65 | 2435 (67.9) | 43 (46.7) | |
| Calendar year of diagnosis | |||
| 1987-1994 | 436 (12.2) | 0 | <.001 |
| 1995-2002 | 1009 (28.1) | 9 (9.8) | |
| 2003-2010 | 1363 (38.0) | 41 (44.6) | |
| 2011-2017 | 777 (21.7) | 42 (45.7) | |
| Primary tumor site | |||
| Skin of head or neck | 2744 (76.5) | 61 (66.3) | .005 |
| Skin of trunk or extremities | 652 (18.2) | 29 (31.5) | |
| Other or unknown | 189 (5.3) | 2 (2.2) | |
| Tumor stage | |||
| Localized | 2494 (69.6) | 70 (76.1) | .39 |
| Regional | 218 (6.1) | 4 (4.3) | |
| Distant | 158 (4.4) | 1 (1.1) | |
| Unknown | 715 (19.9) | 17 (18.5) | |
| Diagnosis of other Muir-Torre syndrome cancersc | |||
| No | 3437 (95.9) | 89 (96.7) | >.99 |
| Yes | 148 (4.1) | 3 (3.3) | |
| Radiation treatmentd | |||
| No | 2795 (93.8) | 82 (93.2) | .83 |
| Yes | 186 (6.2) | 6 (6.8) | |
| Surgical treatmente | |||
| No | 450 (14.1) | 9 (10.1) | .28 |
| Yes | 2733 (85.9) | 80 (89.9) | |
P values were calculated using a Fisher exact test, with the exception of sex, radiation treatment, and surgical treatment, for which P values were calculated using a χ2 test because each group contained ≥5 cases.
Five states/registries (Florida, Hawaii, Michigan, North Carolina, Utah) did not provide data on cause of death and were excluded from the above analysis. In total, cause of death was available for 92 of the 102 transplant recipients (Table 2) with sebaceous carcinoma.
Muir-Torre syndrome cancers include colorectal, urinary bladder, uterine, and ovarian cancers.
Information on radiation treatment was not available for 604 (16.8%) nontransplant patients and 4 (4.3%) solid organ transplant recipients. Cases with missing data were excluded from the χ2 test.
Information on surgical treatment was not available for 402 (11.2%) nontransplant patients and 3 (3.3%) solid organ transplant recipients. Cases with missing data were excluded from the χ2 test.