Table 2.
Association between free IGF-1 or IGFBP-3 with STH infection status based on PCR (a) and microscopy (b).
| STH-infected | STH non-infected | Un-adjusted | Adjusted for age and sex | Adjusted for age, sex, and BMI | Adjusted for age, sex, BMI, and fasting insulin | ||
|---|---|---|---|---|---|---|---|
| (a) | Free IGF-1 (ng/mL) | 0.33 (0.31–0.35) | 0.41 (0.38–0.44) | − 0.090 (− 0.132; − 0.048), P < 0.001 | − 0.089 (− 0.125; − 0.053), P < 0.001 | − 0.078 (− 0.115; − 0.042), P < 0.001 | − 0.068 (− 0.103; − 0.033), P < 0.001 |
| IGFBP-3 (ng/mL) | 424.50 (415.38–433.81) | 423.94 (413.59–434.54) | 0.001 (− 0.014; 0.015), P = 0.937 | ||||
| (b) | Free IGF-1 (ng/mL) | 0.35 (0.33–0.38) | 0.37 (0.35–0.400) | − 0.027 (− 0.069; − 0.015), P = 0.202 | − 0.042 (− 0.078; − 0.006), P = 0.022 | − 0.033 (− 0.068; − 0.003), P = 0.074 | − 0.031 (− 0.066; − 0.003), P = 0.075 |
| IGFBP-3 (ng/mL) | 422.67 (412.79–432.79) | 424.66 (415.51–434.01) | − 0.002 (− 0.016; 0.012), P = 0.777 |
All variables are presented as geometric mean and its 95% confidence interval and were log transformed for analysis. Analysis for the difference between STH-infected and non-infected subjects was performed using linear regression and presented as estimated mean difference and its 95% confidence interval.
BMI body mass index, IGF-1 insulin-like growth factor-1, IGFBP-3 insulin-like growth factor binding protein-3, STH soil-transmitted helminth.