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. 2020 Nov 4;10:18970. doi: 10.1038/s41598-020-75975-w

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Variety of electrophysiological outcomes from OGD using short-term whole-cell recordings. (a) Scheme of the experiment. Cells were sampled using short-term (~ 1 min long) patch-clamp recordings in control conditions and during reperfusion following OGD of various durations (from 1 to 60 min after aSD). (b) Voltage responses (top traces) generated by current injections (bottom traces) recorded from a L4 neuron prior to OGD. The corresponding I-V plot is shown on the right, where the red line shows the range in which R_m was measured, and E_m and R_m are indicated on the right of the I-V curve. (c) Example traces obtained from a L4 neuron which survived OGD with reperfusion started 20 min after aSD. (d) L4 cell which survived OGD with reperfusion started 59 min after aSD, and which has been classified as a putative glial cell due to very negative E_m, high R_m and inability for spike firing. (e) Putative dead cell with low R_m and strongly depolarized E_m.