Fig. 4. Percentage breakdown of the incidence and genetic causes of HRD in CHORD-HRD patients pan-cancer and by cancer type.

Left and right bars represent the HMF and PCAWG datasets respectively. The vertical split in the figure separates cancer types with (left side) and without (right side) ≥10 CHORD-HRD patients in at least one of the datasets. a Frequency of HRD. Cancer types where no frequency of HRD is displayed contain no data in either the HMF or PCAWG datasets. b The gene deficiency associated with HRD. Bar segments are grouped into BRCA2-type HRD genes (BRCA2, RAD51C, PALB2) and BRCA1-type HRD genes (BRCA1 only). c The likely combination of biallelic events in BRCA1/2, RAD51C or PALB2 causing HRD. d Whether the genetic cause of HRD was purely due to somatic events, due to germline predisposition, or unknown. In c, d, “Unknown” and/or “LOH + unknown” bar segments refer to patients where no clear biallelic loss of the aforementioned BRCA1/2, RAD51C, or PALB2 was identified (i.e. clusters 4 and 6 of Fig. 3c). LOH: loss-of-heterozygosity. Only data from samples that passed CHORD’s QC criteria are shown in this figure (MSI absent, ≥50 indels, and ≥30 SVs if a sample was predicted HRD).