Table 3.

Ocular phenotypes based on Piezo1 e756del variants among eyes of individuals of African descent. Data are presented as mean (95% confidence interval) for continuous variables and count (percentage) for categorical variables. RNFL = retinal nerve fiber layer, GCC = ganglion cell complex, VF = visual field, ONH = optic nerve head.

	e756 Deletion			p-value	A vs. B	A vs. C	B vs. C
	A. Heterozygous	B. Homozygous	C. Wild-type
IOP (Max)	n = 356	n = 54	n = 944	0.374	0.206	0.854	0.161
	23.4 (22.2, 24.5)	25.4 (22.5, 28.2)	23.2 (22.5, 23.9)
AL	n = 193	n = 27	n = 466	0.959	0.789	0.856	0.842
	24.2 (23.8, 24.6)	24.1 (23.1, 25.0)	24.2 (23.9, 24.4)
SE	n = 312	n = 45	n = 852	0.281	0.624	0.197	0.281
	− 0.45 (− 0.78, − 0.11)	− 0.21 (− 1.09, 0.66)	− 0.71 (− 0.91, − 0.50)
CCT	n = 154	n = 20	n = 367	0.381	0.189	0.957	0.166
	532.3 (524.2, 540.4)	548.4 (525.8, 570.9)	532.0 (526.8, 537.2)
RNFL Thickness (Spectralis)	n = 159	n = 32	n = 412	0.339	0.150	0.826	0.159
	80.3 (76.3, 84.3)	73.2 (64.4, 82.0)	79.8 (77.3, 82.2)
GCC Thickness (Spectralis)	n = 29	n = 3	n = 73	0.413	0.278	0.664	0.196
	88.1 (81.1, 95.0)	76.3 (56.3, 96.2)	89.9 (85.5, 94.3)
VF 24–2 MD	n = 288	n = 41	n = 772	0.611	0.963	0.337	0.717
	− 8.2 (− 9.5, − 6.9)	− 8.1 (− 11.6, − 4.7)	− 7.5 (− 8.3, − 6.7)
Macula Superficial Density (Avanti)	n = 21	n = 2	n = 60	0.649	0.483	0.451	0.638
	40.5 (37.2, 43.9)	44.9 (33.3, 56.5)	42.0 (40.0, 44.1)
ONH Capillary Density (Avanti)	n = 24	n = 3	n = 62	0.412	0.851	0.230	0.476
	40.6 (37.0, 44.3)	39.6 (30.0, 49.3)	43.3 (41.0, 45.6)