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. 2020 Nov 4;10:19055. doi: 10.1038/s41598-020-76118-x

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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AsIII inhibits erythropoiesis, but not myelopoiesis through interactions with the zinc finger transcription factor, GATA-1. AsIII interacts with the zinc finger motifs (C4) of GATA-1 causing zinc loss and inhibition of DNA and protein binding activities. However, AsIII does not interact with PU.1, a non-zinc finger transcription factor important for myeloid differentiation. The selective effect of AsIII on GATA-1 versus PU.1, results in dyserythropoiesis and produces a shift in the differentiation fate of hematopoietic progenitor cells from erythropoiesis in favor of myelopoiesis.