Table 1.
Parameter estimates of the parent-metabolite model in adults.
| Parent Modela | Metabolite Modelb | ||||
|---|---|---|---|---|---|
| Parameters | Value | RSE (%) | Parameters | Value | RSE (%) |
| Fixed effect | |||||
| CLAPAP/FIR (L/h) | 11.1 | 7 | Vmax (µmol/h) | 0.248 | 13 |
| k for CL/F | 1.5 | 23 | Km (mg/L) | 3.56 | 15 |
| VC/FIR (L) | 30.7 | 14 | CLadduct (L/h) | 2.21 | 16 |
| k for VC | 1.1 | 14 | Vadduct (L) | 7 (Fixed) | - |
| VP/FIR (L) | 19.9 | 12 | |||
| Q/FIR (L/h) | 22.2 | 33 | |||
| Ka1-order in IR & ER (1/h) | 4.33 | 38 | |||
| Fraction0-order in ER | 62% (Fixed) | - | |||
| Lag time0-order in ER (h) | 0.29 | 24 | |||
| Duration0-order in ER (h) | 3.66 | 4 | |||
| FER/FIRc | 0.61 | 10 | |||
| Random effect | |||||
| ω_CLAPAP | 17% | 12 | ω_Vmax | 21% | 26 |
| ω_Vc | 39% | 11 | ω_Km | 63% | 34 |
| ω_Q | 70% | 30 | ω_CLadduct | 29% | 21 |
| ω_Ka | 84% | 30 | |||
| Prop Error | 14% | 21 | Prop Error | 10% | 12 |
| Add Error (mg/L) | 1.23 | 28 | Add Error (µmol/L) | 0.005 | 17 |
a:
This parent model solely served to provide APAP input guiding development of the metabolite model in adults. This parent model was not scaled to children for simulation.
b:
This metabolite model was scaled to children to simulate the adduct profile in conjunction with the literature parent model.
c:
FER/FIR * CLAPAP/FIR serves to derive CLAPAP/FER