Table 3. Results of Selected Asymmetric FC Alkylation Reactions of Indoles with MTNS^a.

entry	cat*	R1	R2	t (min)	conv.b (%)	eec (%)
1	1	H	H	30	55	rac
2	2			30	22	–2
3	1	Me	H	30	90	+12
4	2			30	43	+15
5	1	H	Me	30	81	+3
6	2			30	48	+15
7	1	Me	Me	5	100	+93
8	2			30	100	–21

^aReagents and conditions: catalyst (0.03 mmol, 5.0 mol %), MTNS (0.90 mmol), indole (0.60 mmol), 4 Å molecular sieves (100 mg), and CH₂Cl₂ (4 mL).

^bBased on indole. Determined by ¹H NMR spectroscopy.

^cDetermined by high-performance liquid chromatography (HPLC). Changes in the sign indicate that the opposite enantiomer was preferentially obtained.