Table 1.
Cell-specific transcripts identified from open chromatin.
Cell type | Protein coding | lncRNA | microRNA |
---|---|---|---|
Neuronal | 4075 | 3417 | 87 |
Glutamatergic | 807 | 1123 | 8 |
GABAergic | 834 | 698 | 12 |
non-Neuronal | 6289 | 4485 | 89 |
Oligodendrocyte | 2318 | 1386 | 25 |
Microglia/astrocytes | 1887 | 1957 | 33 |
To infer the transcriptome from chromatin accessibility, genes were linked to cell-specific open chromatin regions by direct overlap of the TSS. “Neuronal” is not simply the sum of “Glutamatergic” and “GABAergic”, as the latter two exclude chromatin that are not specific to either neuronal subtype (Methods). Likewise, “non-Neuronal” is not the sum of the two constituent cell subtypes. For microRNA host genes, only genes encoding one or more conserved microRNA were considered.