| Talcott classification system |
| Patients hospitalized at onset of fever and neutropenia (inpatient at presentation) |
1 |
| Outpatients at presentation but with comorbidities which require hospitalization |
2 |
| Outpatients at presentation with uncontrolled cancer but without comorbidities |
3 |
| Outpatients at presentation without comorbidities and controlled cancer |
4 |
| Multinational association of supportive care of cancer (MASCC) risk-index |
| Burden of febrile neutropenia |
|
| No or mild symptoms: No fever, hemodynamic compromise or clinically significant signs and symptoms of particular site of infection |
5 |
| Moderate symptoms: Any others not included in mild or severe symptoms |
3 |
| Severe symptoms: High grade fever, any hemodynamic compromise or any of the serious complications requiring high dependency unit support |
0 |
| No hypotension (systolic blood pressure > 90 mmHg) |
5 |
| Solid tumor or hematological malignancy with no previous fungal infection |
4 |
| No chronic obstructive pulmonary disease |
4 |
| No dehydration requiring parenteral fluids |
3 |
| Outpatient status |
3 |
| Age < 60 yr |
2 |
| Clinical Index of Stable Febrile Neutropenia (CISNE) score |
| Eastern Cooperative Oncology Group performance status ≥ 2 |
2 |
| Stress-induced hyperglycemia |
2 |
| Chronic obstructive pulmonary disease (on steroids, supplemental oxygen, or bronchodilators) |
1 |
| Chronic cardiovascular disease (excluding single uncomplicated episode of atrial fibrillation) |
1 |
| Mucositis (at least the presence of patchy ulcerations or pseudomembranes, or moderate pain with modified diet) |
1 |
| Monocytes < 200 cells/mm3
|
1 |
