| Enzymes | CHEBI:133004 – bisbenzylisoquinoline alkaloid | Indoles and derivatives | Antineoplastic agents | Kinase | Phosphorylation (GO:0016310) | Neoplasms (C04 (D009369)) | Disease of cellular proliferation (DOID:14566) | 
| CHEBI:50047 – organic amino compound | Macrolides and Analogues | Antivirals for systemic use | Enzyme | Cellular protein modification process (GO:0006464) | Cardiovascular diseases (C14 (D002318)) | Organ system cancer (DOID:0050686) | 
| CHEBI:24698 – hydroxyflavone |  | Drugs for obstructive airway diseases | Camk (CAMK protein kinase group) | Receptor signaling protein activity (GO:0005057) | Urologic diseases (C12.777 (D014570)) | Kidney disease (DOID:557) | 
| CHEBI:24921 – isoquinoline alkaloid |  |  | Ste (STE protein kinase group) | Transferase activity (GO:0016740) | Kidney diseases (C12.777.419 (D007674)) | Urinary system disease (DOID:18) | 
|  |  |  |  | Adenyl nucleotide binding (GO:0030554) |  |  | 
|  | 
| GPCRs | CHEBI:33853 – phenols | Morphinans | Psycholeptics | Small molecule receptor (family A GPCR) | Cell–cell signaling (GO:0007267) | Nervous system diseases (C10 (D009422)) | Disease of mental health (DOID:150) | 
| CHEBI:72720 – flavonoid oligomer | Benzofurans | Drugs for obstructive airway diseases | Transporter | Circulatory system process (GO:0003013) | Cardiovascular diseases (C14 (D002318)) | Central nervous system disease (DOID:331) | 
| CHEBI:33822 – organic hydroxy compound | Stilbenes | Bile and liver therapy | 7TM1 (family A G protein-coupled receptor) | Plasma membrane region (GO:0098590) | Neurologic manifestations (C23.888.592 (D009461)) | Genetic disease (DOID:630) | 
| CHEBI:33635 – polycyclic compound |  | Antihistamines for systemic use | Electrochemical transporter | Transmembrane transporter activity (GO:0022857) | Pituitary diseases (C19.700 (D010900)) | Disease of metabolism (DOID:0014667) | 
|  | 
| Nuclear receptors | CHEBI:51958 – organic polycyclic compound | Steroids and steroid derivatives | Antineoplastic agents | Transcription factor | Intracellular receptor signaling pathway (GO:0030522) | Neoplasms (C04 (D009369)) | Disease of cellular proliferation (DOID:14566) | 
| CHEBI:33635 – polycyclic compound | Morphinans | Corticosteroids for systemic use | Nuclear receptor | Nucleic acid binding transcription factor activity (GO:0001071) | Immune system diseases (C20 (D007154)) | Cancer (DOID:162) | 
| CHEBI:36615 – triterpenoid | Prenol lipids | Anti-acne preparations | Cytochrome P450 | Programmed cell death (GO:0012501) | Hemic and lymphatic diseases (C15 (D006425)) | Immune system disease (DOID:2914) | 
| CHEBI:25872 – pentacyclic triterpenoid | Stilbenes | Analgesics | AUXTRANS (Auxiliary transport protein) | Positive regulation of apoptotic process (GO:0043065) | Skin and connective tissue diseases (C17 (D017437)) | Hypersensitivity reaction disease (DOID:0060056) | 
|  |  | Sex hormones and modulators of the genital system |  |  |  |  | 
|  | 
| Ion channels | CHEBI:47916 – flavonoid | Morphinans | Antihistamines for systemic use | Ste (STE protein kinase group) | Phosphorylation (GO:0016310) | Neoplasms (C04 (D009369)) | Disease of cellular proliferation (DOID:14566) | 
| CHEBI:26004 – phenylpropanoid | Benzopyrans | Beta blocking agents | Camk (CAMK protein kinase group) | Receptor signaling protein activity (GO:0005057) | Skin and connective tissue diseases (C17 (D017437)) | Organ system cancer (DOID:0050686) | 
| CHEBI:26195 – polyphenol | Benzene and substituted derivatives | Drugs for obstructive airway diseases | Ion channel | Transmembrane transport (GO:0055085) | Neurologic manifestations (C10.597 (D009461)) | Gastrointestinal system disease (DOID:77) | 
| CHEBI:38443 – 1-benzopyran |  | Analgesics | Transporter | Cell death (GO:0008219) | Respiratory tract diseases (C08 (D012140)) | Cardiovascular system disease (DOID:1287) | 
|  | 
| Others | CHEBI:33822 – organic hydroxy compound | Macrolactams | Antimycobacterials | Cytosolic other | Proteasome complex (GO:0000502) | Cardiovascular diseases (C14 (D002318)) | Disease of anatomical entity (DOID:7) | 
| CHEBI:26004 – phenylpropanoid | Diazines | Agents acting on the renin–angiotensin system | ATP binding cassette | Ribosome (GO:0005840) | Nervous system diseases (C10 (D009422)) | Cardiovascular system disease (DOID:1287) | 
| CHEBI:47916 – flavonoid | Carboxylic acids and derivatives | Lipid modifying agents | Cytochrome P450 | Antigen processing and presentation (GO:0019882) | Vascular diseases (C14.907 (D014652)) | Disease of cellular proliferation (DOID:14566) | 
| CHEBI:25036 – lignan |  | Antivirals for systemic use | Transporter | Enzyme inhibitor activity (GO:0004857) | Pathological conditions, signs and symptoms (C23 (D013568)) | Primary bacterial infectious disease (DOID:0050338) | 
|  |  |  | Phosphodiesterase |  |  |  | 
|  | 
| Renin (case study) | CHEBI:35352 – organonitrogen compound | Morphinans | Antineoplastic agents | Kinase | Phosphorylation (GO:0016310) | Neoplasms (C04 (D009369)) | Disease of cellular proliferation (DOID:14566) | 
| CHEBI:26188 – polyketide | Macrolides and analogues | Pituitary and hypothalamic hormones and analogues | Tk (TK protein kinase group) | Receptor signaling protein activity (GO:0005057) | Cardiovascular diseases (C14 (D002318)) | Organ system cancer (DOID:0050686) | 
| CHEBI:46845 – N-alkylpiperazine | Lactams | Endocrine therapy | Cmgc (CMGC protein kinase group) | Adenyl nucleotide binding (GO:0030554) | Vascular diseases (C14.907 (D014652)) | Vascular disease (DOID:178) | 
| CHEBI:37578 – halide | Benzodiazepines |  | Agc (AGC protein kinase group) | Guanyl-nucleotide exchange factor activity (GO:0005085) | Digestive system diseases (C06 (D004066)) | Urinary system disease (DOID:18) |