Table 2.
Clinical and demographic characteristics of the nonalcoholic steatohepatitis and simple steatosis population
|
Variables
|
NASH, n = 54
|
Simple steatosis, n = 94
|
P
value
|
| Female | 44 (81.5%) | 67 (71.3%) | 0.169 |
| Age (yr) | 59 (45.8-63) | 57 (47.8-64) | 0.935 |
| BMI (kg/m2) | 32.7 ± 4.8 | 32.8 ± 4.8 | 0.968 |
| WC | 106.6 (100-114) | 105.3 (96-113.8) | 0.306 |
| Arterial hypertension | 39 (72.2%) | 59 (62.8%) | 0.886 |
| Diabetes mellitus | 35 (64.8%) | 34 (36.2%) | 0.007 |
| Dyslipidemia | 45 (83.3%) | 63 (67.0%) | 0.248 |
| Fasting insulin | 16.5 (11.9-31) | 14 (8-18) | 0.055 |
| Fasting glucose (mg/dL) | 112.5 (91-151.5) | 98 (90-112) | 0.019 |
| AST (U/L) | 53.5 (31.7-69) | 30 (23-38) | < 0.001 |
| ALT (U/L) | 61 (36-79.3) | 33 (24-49) | < 0.001 |
| GGT (U/L) | 87 (51.7-164.3) | 39 (27-73.3) | < 0.001 |
| ALP (U/L) | 99 (78-127.5) | 88 (72-116) | 0.075 |
| Total bilirubin (mg/dL) | 0.59 (0.5-0.9) | 0.6 (0.5-0.9) | 0.986 |
| Triglycerides (mg/dL) | 162 (113-227.8) | 163 (109.25-201) | 0.544 |
| Total cholesterol (mg/dL) | 196.4 ± 39.9 | 195.4 ± 42.7 | 0.793 |
| VLDL (mg/dL) | 32 (22.8-45.3) | 32 (22-40.8) | 0.440 |
| HDL (mg/dL) | 46 (37.8-53) | 48 (40-55) | 0.432 |
| LDL (mg/dL) | 108.5 (89-138.4) | 107 (88.5-137.4) | 0.793 |
| Platelets (109/L) | 184 ± 67.4 | 308 ± 1.4 | 0.053 |
| Ferritin (ng/mL) | 109 (56.75-267.5) | 69 (37.2-143.8) | 0.019 |
| D vitamin (ng/mL) | 21.1 (17.55-25.9) | 23.4 (19-28) | 0.086 |
| HOMA-IR | 5.26 (2.97-8.8) | 3.36 (1.77-4.7) | 0.330 |
The data are expressed as n (%), or as mean ± SD for normally distributed variables and as median (interquartile range) when distribution of the variable was skewed. NASH: Nonalcoholic steatohepatitis; BMI: Body mass index; AST: Serum aspartate aminotransferase; VLDL: Very low-density lipoprotein; ALT: Alanine aminotransferase; ALP: Alkaline phosphatase; LDL: Low-density lipoprotein cholesterol.