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. 2020 Oct 20;5(43):28239–28248. doi: 10.1021/acsomega.0c04130

Table 3. Reaction Optimization Using K3PO4 Base Equivalentsa.

2.

entry base equiv temperature (°C) time (h) oxazoline yield (%)b3a oxazole yield (%)b4a
1 K3PO4 0.3 60 12 70 0
2 K3PO4 0.5 60 12 85 0
3 K3PO4 1.0 60 12 90 0
4 K3PO4 1.5 60 12 65 30
5 K3PO4 1 MWc, 60 0.13 94 0
a

Reaction was performed using 1a (1.18 mmol) and 2a (1.18 mmol).

b

Yield of the isolated product.

c

Microwave reactions were carried out in a microwave model no. CATA R (Catalyst Systems, Pune) using a power of 280 W.