Table 2.
Univariable Cox regression analysis for early (before 6 months) and late (after 6 months) periods following intracerebral haemorrhage (ICH)
| ‘Early’ | ‘Late’ | Time‐varying coefficient P‐value | |
|---|---|---|---|
| Age (per year increase) | 1.08 (1.06–1.10) | 1.09 (1.07–1.11) | 0.360 |
| Sex, male | 0.73 (0.53–1.00) | 0.85 (0.62–1.18) | 0.500 |
| Hypertension | 1.43 (1.00–2.04) | 1.08 (0.77–1.52) | 0.270 |
| Hypercholesterolaemia | 1.18 (0.86–1.63) | 1.34 (0.97–1.85) | 0.585 |
| Diabetes mellitus | 1.44 (1.00–2.07) | 1.31 (0.89–1.94) | 0.729 |
| Atrial fibrillation | 2.31 (1.66–3.21) | 2.67 (1.92–3.71) | 0.548 |
| Smoking, current | 0.70 (0.39–1.27) | 0.45 (0.22–0.91) | 0.337 |
| Pre‐existing cognitive impairment | 1.32 (0.75–2.34) | 2.13 (1.39–3.25) | 0.336 |
| Previous cerebral ischaemic event | 1.50 (1.05–2.13) | 1.90 (1.34–2.69) | 0.345 |
| Previous ICH | 1.65 (0.87–3.14) | 1.49 (0.73–3.04) | 0.833 |
| Pre‐event mRS score (per point increase) | 1.56 (1.40–1.74) | 1.50 (1.33–1.69) | 0.610 |
| APOE ε2, presence | 1.40 (0.93–2.11) | 0.70 (0.44–1.13) | 0.032 |
| APOE ε4, presence | 0.65 (0.42–1.02) | 0.90 (0.61–1.32) | 0.280 |
| Medications | |||
| Antiplatelet use prior to ICH | 0.98 (0.68–1.42) | 0.96 (0.66–1.40) | 0.936 |
| Anticoagulant use prior to ICH | 1.97 (1.44–2.71) | 2.73 (1.97–3.78) | 0.164 |
| Antiplatelet use at discharge | 0.95 (0.46–1.93) | 1.23 (0.67–2.28) | 0.582 |
| Anticoagulant use at discharge | 0.85 (0.49–1.48) | 1.48 (0.93–2.35) | 0.134 |
| Clinical features at study entry | |||
| GCS score (per point increase) | 0.80 (0.76–0.84) | 0.93 (0.86–1.00) | 0.001 |
| NIHSS score (per point increase) | 1.11 (1.08–1.14) | 1.00 (0.97–1.04) | <0.0001 |
| Imaging features at study entry | |||
| Lacunes, presence | 1.05 (0.62–1.79) | 1.06 (0.61–1.84) | 0.976 |
| Van Swieten score (WMC, per point increase) | 1.23 (1.11–1.36) | 1.37 (1.23–1.51) | 0.139 |
| ICH location | |||
| Infratentorial | Reference group | ||
| Deep | 1.04 (0.57–1.93) | 0.79 (0.47–1.32) | 0.494 |
| Lobar | 1.42 (0.77–2.62) | 0.67 (0.39–1.14) | 0.067 |
| ICH volume | |||
| <30 mL | Reference group | ||
| 30–60 mL | 2.20 (1.41–3.42) | 1.29 (0.75–2.20) | 0.131 |
| >60 mL | 4.85 (3.01–7.83) | 1.40 (0.62–3.18) | 0.010 |
| Intraventricular extension | 2.20 (1.61–3.02) | 1.55 (1.11–2.18) | 0.141 |
Univariable hazard ratios (HRs) for each characteristic obtained by fitting Cox regression models with time‐varying effects (before/after 6 months). Data are given as HR (95% confidence intervals). The time‐varying coefficient P‐value compares the difference between the early and late HRs. GCS, Glasgow Coma Scale; mRS, modified Rankin scale; NIHSS, National Institutes of Health Stroke Scale.