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. 2020 Nov 5;19:155. doi: 10.1186/s12943-020-01277-4

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 3 — The PVT1 locus is hypomethylated and methylation state negatively correlated with its lncRNA expression in CRC. a The methylation levels at the PVT1 locus in CRC and normal mucosa determined using a 450 K methylation array derived from TCGA database. b Methylation levels at the CpG site (cg23898497) in CRC compared to normal mucosa in all stages in Cohort-1 (P < 0.001, AUC = 0.99) according to the FANTOM5 database. c Methylation levels at the CpG site (cg23898497) in CRC compared to normal mucosa in all stages in Cohort-3 (P < 0.001, AUC = 0.81) as determined by pyrosequencing. d Plot of the PVT1 methylation versus its lncRNA expression (ρ = − 0.4894, P < 0.0001), and the PVT1 methylation versus MYC expression (ρ = − 0.3879, P = 0.0005) in Cohort-1. ***P < 0.001