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. 2020 Nov 4;40(45):8767–8779. doi: 10.1523/JNEUROSCI.0894-20.2020

Figure 6.

Figure 6.

Activation of somatodendritic Gq and Gi DREADDs produces rapid, bidirectional changes in the stability of the cocaine binding site at distal DATs. Example (A) color plots and (B) current versus time plots of DA release and uptake in the presence of the noncanonical DAT inhibitor JHW 007 (30 μm) for Cre–, Cre+:Gq, and Cre+:Gi rats. C, Inhibition of DA uptake following cumulative JHW 007 concentrations (0.3-30 μm). Example (D) color plots and (E) current versus time plots of stimulated DA release and uptake in the presence of the cocaine analog PTT (10 μm) for Cre–, Cre+:Gq, and Cre+:Gi rats. F, Inhibition of DA uptake following cumulative PTT concentrations (0.1-10 μm). Data are mean ± SEM. n = 6 for all groups. Dunnett's post hoc: ***p < 0.001; **p < 0.01; *p < 0.05 versus Cre– control.