Fig. 2.

Conformation-selective tau mAbs detect multiple human tauopathies. Immunohistochemical staining with novel conformation-selective tau mAbs, DMR7 and SKT82, conformation-selective control mAb MC1, and phospho-tau mAb PHF1, demonstrates binding of DMR7 and SKT82 to pathological tau in AD frontal cortex, CBD cingulate cortex, PSP lentiform nucleus, and PiD hippocampus and dentate gyrus but not frontal cortex of cognitively normal control